威尼斯赌博游戏_威尼斯赌博app-【官网】

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威尼斯赌博游戏_威尼斯赌博app-【官网】

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Anatomy and Cell Biology

  1. 威尼斯赌博游戏_威尼斯赌博app-【官网】
  2. Faculties
  3. Faculty of 威尼斯赌博游戏_威尼斯赌博app-【官网】icine
  4. Chairs and professorships
  5. Anatomy and Cell Biology
  6. Research Anatomy and Cell Biology
  7. WG 1 Koch

WG 1 Koch

Neurobiology of environmental metabolic diseases

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Our main interest is research into the central nervous regulation of eating behavior and energy homeostasis. In most modern industrialized societies, the majority of the population is exposed to an obesogenic environment, i.e. living conditions that promote morbid obesity and ultimately promote life-threatening secondary diseases such as diabetes, cancer, heart attack and stroke in those affected. Obesity also increases the likelihood of severe Covid-19 disease progression and is considered a risk factor for neurological diseases.

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In this context, WG 1 focuses on obesity, a diet-related, systemic metabolic disease. The overarching question in this context is how eating habits, diets and natural food components influence the function of our brain and thus our behavior and health.

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In addition, we investigate the physiological and pathological relevance of tissue macrophages for the structural and functional plasticity of defined brain regions. We want to understand how nutrition and other environmental factors affect the functioning of microglia in defined CNS regions.

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Focus I:

Lipidergic neurotransmitters in neural and neuroendocrine circuits ( DFG-GEPRIS)

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Focus II:

Metabolism- and environment-dependent dynamics of intracellular organelles in neural and neuroendocrine circuits

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Focus III:

Microglia-dependent remodeling in the hypothalamus

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Focus IV:

Characterization of macrophages in circumventricular organs

Partners

Prof. Dr. Jae Geun Kim, Incheon Universit?s, Südkorea

PD Dr. Martin Krüger, Universit?t Leipzig

Dr. Luis Varela, Basque Science System, Bilbao, Spanien

Prof. Dr. Tamas Horvath, Yale 威尼斯赌博游戏_威尼斯赌博app-【官网】ical School, New Haven, CT, USA

Funding

Forschungsgro?ger?te: Konfokales Mikroskop, ITM-01

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SFB 1052: Mechanismen der Adipositas, Teilprojekt A07

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Article

Essen fürs Gehirn?

Interview with neurobiologist and anatomist Prof. Dr. Marco Koch

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Publications

2023 | 2022 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2003 | 2002 | 2001

2023
Steingruber Laura, Krabichler Florian, Franzmeier Sophie, Wu Wei, Schlegel Jürgen, Koch Marco. ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control myogenic differentiation of skeletal muscle satellite cells by retinoic acid-dependent and -independent mechanisms. Cell and Tissue Research 2023;394:515-528. https://doi.org/10.1007/s00441-023-03838-7
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2022
Na Junewoo, Park Byong Seo, Jang Doohyeong, Kim Donggue, Tu Thai Hien, Ryu Youngjae, Ha Chang Man, Koch Marco, Yang Sungchil, Kim Jae Geun, Yang Sunggu. Distinct firing activities of the hypothalamic arcuate nucleus neurons to appetite hormones. International Journal of Molecular Sciences 2022;23(5):2609. https://doi.org/10.3390/ijms23052609
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2019
Erdem Merve, M?ckel Diana, Jumpertz Sandra, John Cathleen, Fragoulis Athanassios, Rudolph Ines, Wulfmeier Johanna, Springer Jochen, Horn Henrike, Koch Marco, Lurje Georg, Lammers Twan, Olde Damink Steven, Kroft Gregory, Gremse Felix, Cramer Thorsten. Macrophages protect against loss of adipose tissue during cancer cachexia. Journal of Cachexia, Sarcopenia and Muscle 2019;10(5):1128-1142. https://doi.org/10.1002/jcsm.12450
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2018
Horn Henrike, B?hme Beatrice, Dietrich Laura, Koch Marco. Endocannabinoids in body weight control. Pharmaceuticals 2018;11(2):55. https://doi.org/10.3390/ph11020055
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García-Cáceres Cristina, Balland Eglantine, Prevot Vincent, Luquet Serge, Woods Stephen C., Koch Marco, Horvath Tamas L., Yi Chun-Xia, Chowen Julia A., Verkhratsky Alexei, Araque Alfonso, Bechmann Ingo, Tsch?p Matthias H.. Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism. Nature Neuroscience 2018;22(1):7-14. https://doi.org/10.1038/s41593-018-0286-y
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Tebbenkamp Andrew T. N., Varela Luis, Choi Jinmyung, Paredes Miguel I., Giani Alice M., Song Jae Eun, Sestan-Pesa Matija, Franjic Daniel, Sousa André M. M., Liu Zhong-Wu, Li Mingfeng, Bichsel Candace, Koch Marco, Szigeti-Buck Klara, Liu Fuchen, Li Zhuo, Kawasawa Yuka I., Paspalas Constantinos D., Mineur Yann S., Prontera Paolo, Merla Giuseppe, Picciotto Marina R., Arnsten Amy F. T., Horvath Tamas L., Sestan Nenad. The 7q11.23 protein DNAJC30 interacts with ATP synthase and links mitochondria to brain development. Cell 2018;175(4):1088-1104.e23. https://doi.org/10.1016/j.cell.2018.09.014
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2017
Koch Marco. Cannabinoid receptor signaling in central regulation of feeding behavior: a mini-review. Frontiers in Neuroscience 2017;11:293. https://doi.org/10.3389/fnins.2017.00293
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Morozov Yury M., Koch Marco, Rakic Pasko, Horvath Tamas L.. Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleus. Molecular Metabolism 2017;6(4):374-381. https://doi.org/10.1016/j.molmet.2017.01.004
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Koch Marco. Kopf. In: Waschke Jens, editor. Kurzlehrbuch Anatomie. München: Elsevier; 2017. p. 265-321.
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Quarta Carmelo, Clemmensen Christoffer, Zhu Zhimeng, Yang Bin, Joseph Sini S., Lutter Dominik, Yi Chun-Xia, Graf Elisabeth, García-Cáceres Cristina, Legutko Beata, Fischer Katrin, Brommage Robert, Zizzari Philippe, Franklin Bernardo S., Krueger Martin, Koch Marco, Vettorazzi Sabine, Li Pengyun, Hofmann Susanna M., Bakhti Mostafa, Bastidas-Ponce Aimée, Lickert Heiko, Strom Tim M., Gailus-Durner Valerie, Bechmann Ingo, Perez-Tilve Diego, Tuckermann Jan, Hrabě de Angelis Martin, Sandoval Darleen, Cota Daniela, Latz Eicke, Seeley Randy J., Müller Timo D., DiMarchi Richard D., Finan Brian, Tsch?p Matthias H.. Molecular integration of incretin and glucocorticoid action reverses immunometabolic dysfunction and obesity. Cell Metabolism 2017;26(4):620-632.e6. https://doi.org/10.1016/j.cmet.2017.08.023
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2016
Jin Sungho, Kim Jae Geun, Park Jeong Woo, Koch Marco, Horvath Tamas L., Lee Byung Ju. Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis. Scientific Reports 2016;6(1):29424. https://doi.org/10.1038/srep29424
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2015
Kim Jae?Geun, Sun Ben-Hua, Dietrich Marcelo?O., Koch Marco, Yao Gang-Qing, Diano Sabrina, Insogna Karl, Horvath Tamas?L.. AgRP neurons regulate bone mass. Cell Reports 2015;13(1):8-14. https://doi.org/10.1016/j.celrep.2015.08.070
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Koch Marco, Varela Luis, Kim Jae Geun, Kim Jung Dae, Hernández-Nu?o Francisco, Simonds Stephanie E., Castorena Carlos M., Vianna Claudia R., Elmquist Joel K., Morozov Yury M., Rakic Pasko, Bechmann Ingo, Cowley Michael A., Szigeti-Buck Klara, Dietrich Marcelo O., Gao Xiao-Bing, Diano Sabrina, Horvath Tamas L.. Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature 2015;519(7541):45-50. https://doi.org/10.1038/nature14260
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Koch Marco, Ferreirós Nerea, Geisslinger Gerd, Dehghani Faramarz, Korf Horst-Werner. Rhythmic control of endocannabinoids in the rat pineal gland. Chronobiology International 2015;32(6):869-874. https://doi.org/10.3109/07420528.2015.1041596
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2014
Kim Jae Geun, Suyama Shigetomo, Koch Marco, Jin Sungho, Argente-Arizon Pilar, Argente Jesús, Liu Zhong-Wu, Zimmer Marcelo R, Jeong Jin Kwon, Szigeti-Buck Klara, Gao Yuanqing, Garcia-Caceres Cristina, Yi Chun-Xia, Salmaso Natalina, Vaccarino Flora M, Chowen Julie, Diano Sabrina, Dietrich Marcelo O, Tsch?p Matthias H, Horvath Tamas L. Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nature Neuroscience 2014;17(7):908-910. https://doi.org/10.1038/nn.3725
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Koch Marco, Horvath T. L.. Molecular and cellular regulation of hypothalamic melanocortin neurons controlling food intake and energy metabolism. Molecular Psychiatry 2014;19(7):752-761. https://doi.org/10.1038/mp.2014.30
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2013
Morozov Yury M., Dominguez Martin H., Varela Luis, Shanabrough Marya, Koch Marco, Horvath Tamas L., Rakic Pasko. Antibodies to cannabinoid type 1 receptor co-react with stomatin-like protein 2 in mouse brain mitochondria. European Journal of Neuroscience 2013;38(3):2341-2348. https://doi.org/10.1111/ejn.12237
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Benz Alexander H., Renné Christoph, Maronde Erik, Koch Marco, Grabiec Urszula, Kallendrusch Sonja, Rengstl Benjamin, Newrzela Sebastian, Hartmann Sylvia, Hansmann Martin-Leo, Dehghani Faramarz. Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma. PLoS ONE 2013;8(12):e81675. https://doi.org/10.1371/journal.pone.0081675
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Kallendrusch Sonja, Kremzow Stine, Nowicki Marcin, Grabiec Urszula, Winkelmann Ria, Benz Alexander, Kraft Robert, Bechmann Ingo, Dehghani Faramarz, Koch Marco. The G protein-coupled receptor 55 ligandl-α-lysophosphatidylinositol exerts microglia-dependent neuroprotection after excitotoxic lesion. Glia 2013;61(11):1822-1831. https://doi.org/10.1002/glia.22560
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2012
Kallendrusch Sonja, Hobusch Constance, Ehrlich Angela, Nowicki Marcin, Ziebell Simone, Bechmann Ingo, Geisslinger Gerd, Koch Marco, Dehghani Faramarz. Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage. PLoS ONE 2012;7(12):e51208. https://doi.org/10.1371/journal.pone.0051208
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Hezel Marcus, Ebrahimi Fahim, Koch Marco, Dehghani Faramarz. Propidium iodide staining: a new application in fluorescence microscopy for analysis of cytoarchitecture in adult and developing rodent brain. Micron 2012;43(10):1031-1038. https://doi.org/10.1016/j.micron.2012.04.006
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Koch Marco, Horvath Tamas L.. Reward aspects of gastrointestinal hormones mediated by brain G protein–coupled receptors. Biological Psychiatry 2012;72(5):340-342. https://doi.org/10.1016/j.biopsych.2012.06.031
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Kallendrusch Sonja, Hobusch Constance, Ehrlich Angela, Ziebell Simone, Ueda Natsuo, Geisslinger Gerd, Koch Marco, Dehghani Faramarz. Site-specific and time-dependent activation of the endocannabinoid system after transection of long-range projections. PLoS ONE 2012;7(3):e33537. https://doi.org/10.1371/journal.pone.0033537
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Grabiec Urszula, Koch Marco, Kallendrusch Sonja, Kraft Robert, Hill Kerstin, Merkwitz Claudia, Ghadban Chalid, Lutz Beat, Straiker Alex, Dehghani Faramarz. The endocannabinoid N-arachidonoyldopamine (NADA) exerts neuroprotective effects after excitotoxic neuronal damage via cannabinoid receptor 1 (CB1). Neuropharmacology 2012;62(4):1797-1807. https://doi.org/10.1016/j.neuropharm.2011.11.023
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Ebrahimi Fahim, Koch Marco, Pieroh Philipp, Ghadban Chalid, Hobusch Constance, Bechmann Ingo, Dehghani Faramarz. Time dependent neuroprotection of mycophenolate mofetil: effects on temporal dynamics in glial proliferation, apoptosis, and scar formation. Journal of Neuroinflammation 2012;9(1):9:89. https://doi.org/10.1186/1742-2094-9-89
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2011
Koch Marco, Kreutz Susanne, B?ttger Charlotte, Grabiec Urszula, Ghadban Chalid, Korf Horst-Werner, Dehghani Faramarz. The cannabinoid WIN 55,212-2-mediated protection of dentate gyrus granule cells is driven by CB1 receptors and modulated by TRPA1 and Cav2.2 channels. Hippocampus 2011;21(5):554-564. https://doi.org/10.1002/hipo.20772
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2010
Yasuo Shinobu, Koch Marco, Schmidt Helmut, Ziebell Simone, Bojunga Joerg, Geisslinger Gerd, Korf Horst-Werner. An endocannabinoid system is localized to the hypophysial pars tuberalis of Syrian hamsters and responds to photoperiodic changes. Cell and Tissue Research 2010;340(1):127-136. https://doi.org/10.1007/s00441-010-0930-7
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Ebrahimi Fahim, Hezel Marcus, Koch Marco, Ghadban Chalid, Korf Horst-Werner, Dehghani Faramarz. Analyses of neuronal damage in excitotoxically lesioned organotypic hippocampal slice cultures. Annals of Anatomy - Anatomischer Anzeiger 2010;192(4):199-204. https://doi.org/10.1016/j.aanat.2010.06.002
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Koch Marco, Kreutz Susanne, B?ttger Charlotte, Benz Alexander, Maronde Erik, Ghadban Chalid, Korf Horst-Werner, Dehghani Faramarz. Palmitoylethanolamide protects dentate gyrus granule cells via peroxisome proliferator-activated receptor-alpha. Neurotoxicity Research 2010;19(2):330-340. https://doi.org/10.1007/s12640-010-9166-2
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Bishay Philipp, Schmidt Helmut, Marian Claudiu, H?ussler Annett, Wijnvoord Nina, Ziebell Simone, Metzner Julia, Koch Marco, Myrczek Thekla, Bechmann Ingo, Kuner Rohini, Costigan Michael, Dehghani Faramarz, Geisslinger Gerd, Tegeder Irmgard. R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids. PLoS ONE 2010;5(5):e10628. https://doi.org/10.1371/journal.pone.0010628
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2009
Kreutz Susanne, Koch Marco, B?ttger Charlotte, Ghadban Chalid, Korf Horst-Werner, Dehghani Faramarz. 2-Arachidonoylglycerol elicits neuroprotective effects on excitotoxically lesioned dentate gyrus granule cells via abnormal-cannabidiol-sensitive receptors on microglial cells. Glia 2009;57(3):286-294. https://doi.org/10.1002/glia.20756
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2008
Koch Marco, Habazettl Iris, Dehghani Faramarz, Korf Horst-Werner. The rat pineal gland comprises an endocannabinoid system. Journal of Pineal Research 2008;45(4):351-360. https://doi.org/10.1111/j.1600-079x.2008.00597.x
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2007
Kreutz Susanne, Koch Marco, Ghadban Chalid, Korf Horst-Werner, Dehghani Faramarz. Cannabinoids and neuronal damage: differential effects of THC, AEA and 2-AG on activated microglial cells and degenerating neurons in excitotoxically lesioned rat organotypic hippocampal slice cultures. Experimental Neurology 2007;203(1):246-257. https://doi.org/10.1016/j.expneurol.2006.08.010
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2006
Koch Marco, Dehghani Faramarz, Habazettl Iris, Schomerus Christof, Korf Horst-Werner. Cannabinoids attenuate norepinephrine-induced melatonin biosynthesis in the rat pineal gland by reducing arylalkylamine N-acetyltransferase activity without involvement of cannabinoid receptors. Journal of Neurochemistry 2006;98(1):267-278. https://doi.org/10.1111/j.1471-4159.2006.03873.x
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2003
Koch Marco, Mauhin Viviane, Stehle J?rg H., Schomerus Christof, Korf Horst-Werner. Dephosphorylation of pCREB by protein serine/threonine phosphatases is involved in inactivation of Aanat gene transcription in rat pineal gland. Journal of Neurochemistry 2003;85(1):170-179. https://doi.org/10.1046/j.1471-4159.2003.01651.x
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2002
Koch Marco, Korf H.-W.. Distribution of regulatory subunits of protein kinase A and A kinase anchor proteins (AKAP 95, 150) in rat pinealocytes. Cell and Tissue Research 2002;310(3):331-338. https://doi.org/10.1007/s00441-002-0633-9
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2001
Vollmayer Petra, Koch Marco, Braun Norbert, Heine Petra, Servos J?rg, Israr Eltahmash, Kegel Birgit, Zimmermann Herbert. Multiple ecto-nucleotidases in PC12 cells: identification and cellular distribution after heterologous expression. Journal of Neurochemistry 2001;78(5):1019-1028. https://doi.org/10.1046/j.1471-4159.2001.00480.x
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