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What content do we teach? Why do we rely on body donations? What research approaches are we interested in? You can find an overview of these topics on our website.

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Funding by the German Research Foundation (DFG)

Dr. Maryam Keshavarz: Exploring the influence of tuft cells in the biliary system

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Gallstone disease and other conditions affecting the bile ducts - such as inflammation and bile duct caner (cholangiocarcinoma) - are common and often require surgery. In Europe, about 20% of people develop gallstones at some point. In Germany alone, more than 175.000 gallbladder removals are performed each year. Despite how widespread these conditions are, the exact causes of inflammation and disease in the bile system are still not well understood. The gallbladder plays a key role in storing and controlling bile, which is essential for digesting fat and maintaining metabolic health.

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Dr. Maryam Keshavarz and her team are working to change that. In a project funded by the German Research Foundation (DFG) with 315.000 €, her research group is studying tuft cells - rare sensory cells found in the lining of the gallbladder. Theses cells can sence chemical and microbial signals and may help regulate immune responses and tissue function. Using different genetically modified mouse modells and samples of human gallbladder tissues, the researchers are investigating how tuft cells interact with other cell types during inflammation and disease. Their goal is to unvocer new signaling pathways that contribute to the development of gallstones and related conditions. By revealing the role of tuft cells in the gallbladder, this research opens new perspectives on how the biliary system maintains balance and responds to stress. These findings could lead to innovative diagnostic tools amd more precise, targeted therapies for biliary diseases.

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For more information click here.

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Academic Counselor
Anatomy and Cell Biology

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Job Offers

We are looking for: Student Assistant (m/f/d)

...in the project ¡°Brush cells and their function in the bile duct system and gastrointestinal tract¡±.

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On our own behalf

June 25, 2024

Award for medical teaching competence

Dr. Laura Steingruber was awarded the "Certificate of ÍþÄá˹¶Ä²©ÓÎÏ·_ÍþÄá˹¶Ä²©app-¡¾¹ÙÍø¡¿ical Didactics of the Bavarian Universities", level 1 - basic level, for medical teaching competence in the summer semester 2024. As part of the further training, medical and university didactic workshops were completed and a final teaching evaluation was carried out.

Sept. 25, 2024

Super-resolution microscopy now also in Augsburg

With a STED microscope, model STEDyCON from Abberior Instruments, we are launching imaging with nanoscale resolution. For cooperation please contact Prof. Dr. rer. nat. Katrin Willig phone number: +49 (0) 821 598-71241.

Aug. 12, 2024

Origin of phagocytes in the vitreous body of the eye clarified - Hope for diabetic retinopathy

A team led by Augsburg cell biologist and anatomist Prof. Dr. Peter Wieghofer has shown that macrophages develop in the vitreous body of the eye during the embryonic stage. Until now, it was assumed that they regularly regenerate from blood cells in the course of life. This finding is important for the treatment of diseases such as diabetic retinopathy. The specialist article on this was recently published in the Journal of Neuroinflammation.

Newsflash publications

"Bitter tastants relax the mouse gallbladder smooth muscle independent of signaling through tuft cells and bitter taste receptors"

In our publication, published in August 2024, we investigated bitter compounds as relaxants for gallbladder smooth muscle. Our findings suggest new ways to treat gallbladder disease caused by abnormal muscle contractions. The study shows that bitter compounds such as dantonium, quinine and dextromethorphan effectively relax gallbladder muscles, independent of the traditional bitter taste receptors and specific cell types previously thought to be relevant. Our results suggest that these compounds act directly on the smooth muscle cells of the gallbladder.

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Keshavarz Maryam, Ruppert Anna-Lena, Meiners Mirjam, Poharkar Krupali, Liu Shuya, Mahmoud Wafaa, Winterberg Sarah, Hartmann Petra, Mermer Petra, Perniss Alexander, Offermanns Stefan, Kummer Wolfgang, Sch¨¹tz Burkhard. https://doi.org/10.1038/s41598-024-69287-6 PDF | BibTeX | RIS | DOI

Current Publications

Keshavarz Maryam, Ruppert Anna-Lena, Meiners Mirjam, Poharkar Krupali, Liu Shuya, Mahmoud Wafaa, Winterberg Sarah, Hartmann Petra, Mermer Petra, Perniss Alexander, Offermanns Stefan, Kummer Wolfgang, Sch¨¹tz Burkhard. Bitter tastants relax the mouse gallbladder smooth muscle independent of signaling through tuft cells and bitter taste receptors. https://doi.org/10.1038/s41598-024-69287-6
PDF | BibTeX | RIS | DOI
Perniss Alexander, Boonen Brett, Tonack Sarah, Thiel Moritz, Poharkar Krupali, Alnouri Mohamad Wessam, Keshavarz Maryam, Papadakis Tamara, Wiegand Silke, Pfeil Uwe, Richter Katrin, Althaus Mike, Oberwinkler Johannes, Sch¨¹tz Burkhard, Boehm Ulrich, Offermanns Stefan, Leinders-Zufall Trese, Zufall Frank, Kummer Wolfgang. A succinate/SUCNR1-brush cell defense program in the tracheal epithelium. https://doi.org/10.1126/sciadv.adg8842
PDF | BibTeX | RIS | DOI

Locations

Until the completion of the new ITM research building on the medical campus of the ÍþÄá˹¶Ä²©ÓÎÏ·_ÍþÄá˹¶Ä²©app-¡¾¹ÙÍø¡¿ of Augsburg? (progress and live camera), the chair is currently using interim research space and offices in the Business Park in Garching near Munich and in the SIGMA Technopark in Augsburg.

Contact

Visiting address administration:

ÍþÄá˹¶Ä²©ÓÎÏ·_ÍþÄá˹¶Ä²©app-¡¾¹ÙÍø¡¿ of Augsburg

Anatomy und Cell Biology

SIGMA-Technopark

Building 10f, 1st floor

Werner-von-Siemens-Stra?e 6

86159 Augsburg

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Mailing address:

ÍþÄá˹¶Ä²©ÓÎÏ·_ÍþÄá˹¶Ä²©app-¡¾¹ÙÍø¡¿ of Augsburg

Faculty of ÍþÄá˹¶Ä²©ÓÎÏ·_ÍþÄá˹¶Ä²©app-¡¾¹ÙÍø¡¿icine

Anatomy und Cell Biology

Universit?tsstra?e 2

86159 Augsburg

Visiting address laboratory Augsburg:

ÍþÄá˹¶Ä²©ÓÎÏ·_ÍþÄá˹¶Ä²©app-¡¾¹ÙÍø¡¿ of Augsburg

Anatomy und Cell Biology

SIGMA-Technopark

Building 10f, 4th floor

Werner-von-Siemens-Stra?e 6

86159 Augsburg

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Visiting address laboratory Garching:

ÍþÄá˹¶Ä²©ÓÎÏ·_ÍþÄá˹¶Ä²©app-¡¾¹ÙÍø¡¿ of Augsburg

Anatomy und Cell Biology

Business Park Garching

Parkring 11-13

85748 Garching near Munich

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Lageplan Business Park Garching
? ÍþÄá˹¶Ä²©ÓÎÏ·_ÍþÄá˹¶Ä²©app-¡¾¹ÙÍø¡¿ of Augsburg

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