Global temperature increases and more frequent heat waves pose a growing challenge to public health. Acute and chronic heat exposure affect numerous physiological systems, including thermoregulation, cardiovascular load, immune function, and gastrointestinal barrier integrity. The molecular mechanisms underlying successful heat acclimatization in humans are only partially understood. The planned dissertation aims to investigate the mechanisms of heat adaptation in humans, with a particular focus on changes in gastrointestinal barrier function and potential endotoxin-induced immune responses (“leaky gut”), as well as the relevance of nutrition in these adaptation processes.

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• Human study with repeated heat exposure, including assessment of physiological parameters and collection of blood samples
• Analysis of molecular markers using ELISA/flow cytometry

• Intensive supervision and methodological training
• Opportunity to present your own data at conferences and to prepare publications
• State-of-the-art laboratory methods
• A dynamic, research-oriented team